用于治疗雄激素缺乏的联合治疗

Combination therapy for treating androgen deficiency

Abstract

The present invention relates to a combination therapy for elevating testosterone levels in male mammals in which an antiestrogen or pharmaceutically acceptable salt thereof is co-administered to the mammal with an additional therapeutic agent selected from an androgen and an aromatase inhibitor. The invention is also directed to a combination therapy for treating males with hypogonadism and disorders related thereto, including reduction of muscle mass. limitation of body performance capacity, reduction of bone density, reduction of libido, reduction of potency, reduction of benign prostatic hyperplasia and infertility.
本发明涉及一种用于升高雄性哺乳动物中的睾酮水平的联合治疗,其中将抗雌激素剂或其药学上可接受的盐与选自雄激素和芳香酶抑制剂的另外的药学活性剂共同施用给哺乳动物。本发明也涉及一种用于治疗具有性腺功能减退症和与其有关的障碍的雄性动物的联合治疗,所述障碍包括肌肉质量的减少、身体执行能力的限制、骨密度的下降、性欲减少、效能下降、良性前列腺增生减少和不育。

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Patent Citations (1)

    Publication numberPublication dateAssigneeTitle
    CN-101163467-AApril 16, 2008雷普罗斯治疗公司Dosing regimes for trans-clomiphene

NO-Patent Citations (2)

    Title
    LOVES S等: "Letrozole once a week normalizes serum testosterone in obesity related male hypogonadism", 《EUR J ENDOCRINOL》
    R.S.TAN,等: "An unusual case of vascular hypogonadism treated with clomiphene citrate and testosterone replacement", 《ANDROLOGIA》

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