海滨锦葵素在制备防治炎症相关疾病药物中的用途

Application of kosteletzkya malvidin in preparation of medicines for preventing and treating inflammation-related diseases

Abstract

The invention belongs to the field of natural medicines, and relates to application of a specific monomer kosteletzkya malvidin in kosteletzkya virginica in preparation of medicine compositions, in particular to application of specific monomer kosteletzkya malvidin in kosteletzkya virginica in preparation of medicine compositions for inflammation-related diseases. The research result of an in-vitro inflammation model experiment shows that the kosteletzkya malvidin can be used for reducing generation of prostaglandin E2 induced by inflammation and release of nitric oxide. An animal experiment finds that the kosteletzkya malvidin can be used for inhibiting mouse ear swelling which is stimulated by phorbol ester. The experiments prove that the kosteletzkya malvidin has obvious anti-inflammation effects on the inflammation-related diseases and can be used for preparing the medicines for preventing and treating the inflammation-related diseases comprising rheumatic arthritis, inflammatory bowel diseases, neurodegenerative diseases, septic shock and the like.
本发明属天然药物领域,涉及海滨锦葵中的特异单体海滨锦葵素在制备药物组合物中的应用,尤其是在制备炎症相关疾病的药物组合物中的应用。本发明通过体外炎症模型实验研究,结果显示了所述的海滨锦葵素能减少炎症诱导的前列腺素E2的产生和一氧化氮的释放;动物实验发现,海滨锦葵素能抑制佛波酯刺激的小鼠耳肿胀。实验证实,所述的海滨锦葵素对炎症相关疾病具有明显的抗炎作用,可制备防治炎症相关疾病的药物。所述炎症性疾病包括风湿性关节炎、炎症性肠病、神经退化性疾病、脓毒性休克等。

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